Reporting on the move, Graham Cluley, Sophos' senior technology consultant, said that the account was taken offline after the rapper's Twitter account was hacked over the weekend and the hacker posted a series of joke messages.
"A hacker, who seemingly guessed the singer's password, sent a series of bizarre messages to Lil Wayne's 1.2 million followers – including rude tweets to celebrity pals 50 Cent, Soulja Boy and The Game. According to AllHipHop.com, some of the language used was highly offensive", he noted.
The Sophos senior technology consultant went on to say that Lil' Wayne has now shut down his Twitter account, which went by the name @liltunechi.
"To be honest, he hasn't had the best of times on Twitter - his page was previously hacked late last year, with fake news being posted about upcoming performances. Clearly if he can't keep control of his Twitter account, it's better that it be disabled", he added.
According to Cluley, if nothing else, this case proves that just because a Twitter account is "verified", it doesn't mean that it really is the celebrity (or an authorised representative) who is doing the tweeting.
Other celebrities who have had their Twitter accounts hacked in the past include Axl Rose, politician Ed Miliband, Britney Spears and plummy-voiced TV property crumpet Kirsty Allsopp, he noted in his security blog.